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Oral Thin Films Technology | Zim Laboratories Limited

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Oral Thin Films Technology

SAY GOODBYE TO THE PILL

THE PILL PROBLEM

Most of us pop a pill for aches, colds or the occasional upset stomach without a thought. But there is a sizable population for whom swallowing or even administering a pill is a big task. Small children, geriatric patients, mentally challenged, nauseated, unconscious and persons with certain forms of disability form a part of this group. Therefore there was an urgent need for finding a new drug delivery system that makes it easier to take lifesaving medication.

ENTER THINORAL® TECHNOLOGY

Thinoral® technology or Oral Thin Film (OTF) is the answer to the pill problem. The instantly dissolving strip carries lifesaving medication on it. All you have to do is place it on your tongue and the medicine is administered.

Thinoral® offers improved patient compliance with ease of self-administration, storage and transportation.

The rapidly dissolving strips don’t require water or any other liquid for administration.

It offers accurate and precise dosing and has the ability to deliver small doses (milli to nano).

Thinoral® technology is relatively more useful in emergency situations such as emesis, acute pain, motion sickness, etc.

With Thinoral® technology a relatively lower dosage required as it avoids the first pass metabolic pathway (when administered sublingually or buccally).

The technology is completely safe and non-invasive.

Thinoral® technology has relatively lower development costs & needs lesser clinical studies as compared to developing new chemical entities/drugs.

OTF DISPERSION FORMS

CONVERSION OF IM/SC INJECTABLE DOSAGE FORMS INTO SUBLINGUAL FORMULATIONS

It is a non-invasive mode of administration.

Thinoral® is a proprietary technology and non-infringing process.

It will be filed as an NDA/ANDA application requiring clinical trails.

 

SUBLINGUAL/BUCCAL FILMS

Thinoral® is an alternative for injectable mode of drug delivery.

It has improved bioavailability as the first pass metabolism is avoided.

Thinoral® is a proprietary technology and non-infringing process.

It can be filed as an ANDA application.

 

THE ZIM ADVANTAGE

Oral Thin Films (OTF) is the latest addition to ZIM’s stable.

It is one of the few companies globally and one of the very few companies in India to have mastered the OTF technology.

ZIM Oral Thin Film (OTF) Technology is patented as Thinoral® with about 19 applied product/proccess patents for oral films globally.

It has received 24 DCGI product approvals & is awaiting 14 in India and 13 product approvals overseas.

Its rapidly dissolving, non-sticky films have a drug loading capacity as high as 100 mg of the active drug. The faster release profile alleviates solubility issues in poorly soluble drugs.

Unlike orally disintegrating tablets that are manufactured using lyophilisation or low compression pressure, the Thinoral® strips are flexible and offer ease of storage and transportation.

Thinoral® technology could also be used for delivery of drugs through sublingual and buccal absorption routes, showing improved bioavailability by avoiding first pass metabolism.

OTF PRODUCTS

 

 

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ZIM’S PARTNERS IN OTF

ZIM LABORATORIES OTF FACILITY

The state-of-the-art OTF manufacturing facility is capable of manufacturing 324 million strips per annum.

This is a dedicated facility for manufacturing of OTF in various treatment areas and has separate nutraceutical and pharmaceutical manufacturing areas.

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