Thinoral Technology

Oral Thin Films (OTF) is the latest addition to ZIM Labs stable.

It is one of the few companies globally and one of the very few companies in India to have mastered the OTF technology.

ZIM Labs Oral Thin Film (OTF) Technology is patented as Thinoral® with about 19 applied product/proccess patents for oral films globally.

It has received 24 DCGI product approvals & is awaiting 14 in India and 13 product approvals overseas.

Its rapidly dissolving, non-sticky films have a drug loading capacity as high as 100 mg of the active drug. The faster release profile alleviates solubility issues in poorly soluble drugs.

Unlike orally disintegrating tablets that are manufactured using lyophilisation or low compression pressure, the Thinoral® strips are flexible and offer ease of storage and transportation.

Thinoral® technology could also be used for delivery of drugs through sublingual and buccal absorption routes, showing improved bioavailability by avoiding first pass metabolism.

OTF
Dispersion Forms

Conversion of IM/SC injectable dosage forms into Sublingual Formulations

  • Non invasive mode of administration
  • Proprietary technology & non-infringing process
  • Will be filed as an NDA/ANDA application requiring clinical trails

Sublingual/
Buccal Films

  • Alternative for injectable
  • Improved bioavailability as first pass metabolism is avoided
  • Proprietary technology and non-infringing process
  • Can be filed as an ANDA application

ZIM Labs Products permissions and registrations

ZIM Labs has filed 37 patents, Registered over 170 formulations in various markets (mainly RoW).

OTF Products

Sr. No. Product Name Strength (MG) Therapeutic use Pack Presentation Brand Name
1 Ondansetron (Hydrochloride) 4 / 8 Anti-Emetic 10 X 1 AAP ZIMONZ ODS®
2 Tadalafil 5 / 10 / 20 Benign Prostatic Hyperplasia,
Erectile Dysfunction
10 X 1 AAP® ZIMFIL®
3 Sildenafil (Citrate) 25 / 50 Erectile Dysfunction 10 X 1 AAP ZIMAGRATM
4 Methylcobalamin 1000 / 1500 mcg Vitamin B12 Suppliment
Diabetic Neuropathy
10 X 1 AAP NUROTHINTM
5 Levocetirizine Dihydrochloride 5 Anti-Allergic/ Nasal Decongestant 10 X 1 AAP LEVCETHIN®
6 Montelukast (Sodium) 10 Anti-Asthmatic / Anti-Allergic 10 X 1 AAP LUKASTIL®
7 Vitamin D3 400/600/800/1000/2000/60000 IU Vitamin D3 Supplement 10 X 1 AAP FINEVIT D3®
8 Nicotine (Polacrilex) 2 For Smoking Cessation 10 X 1 AAP NICOTHINTM
9 Simethicone 62.5 Anti-Flatulent 10 X 1 AAP GASOTHINTM
10 Melatonin 1 / 3 / 5 Sedative & Hypnotic 10 X 1 AAP ZIMELT®
11 Mouth Freshener ---- Mouth Freshener (Mint, Lemon, Mango, Orange & Pan Masala Flavour) 30 Strips/Films per cassette ZIMINTATM
12 Rizatriptan (Benzoate) 5 / 10 Anti-Migraine 5 X 1 AAP RIZATHIN ®
13 Folic Acid 0.5 Dietary Supplement 10 X 1 AAP FOLIZIMTM

Abbreviation: AAP = Alu-Alu Pouch

Sr. No. Product Name Strength (MG) Therapeutic use Pack Presentation Brand Name
1 Ondansetron (Hydrochloride) 2 Anti-Emetic 10 X 1 AAP ZIMONZ ODS®
2 Tadalafil 2.5 Benign Prostatic Hyperplasia, Erectile Dysfunction 10 X 1 AAP ZIMFIL®
3 Levocetirizine Dihydrochloride 2.5 Anti-Allergic / Nasal Decongestant 10 X 1 AAP LEVCETHIN®
4 Montelukast (Sodium) 4 / 5 Anti-Asthmatic/ Anti-Allergic 10 X 1 AAP LUKASTIL®
5 Voglibose 0.2 / 0.3 Anti-Diabetic 10 X 1 AAP VOGLITHINTM
6 Zolmitriptan 2.5/ 5 Anti-Migraine 10 X 1 AAP ZOLMITHIN®
7 Melatonin 0.5 Sedatives & Hypnotics 10 X 1 AAP ZIMELT®
8 Clonazepam 0.5 / 1 / 2 Anxiolytic & Anti - Epileptic 10 X 1 AAP ZICLOPAMTM
9 Donepezil Hydrochloride 5 / 10 Anti - Alzheimer 10 X 1 AAP
10 Niacin (Vitamin B3) 75 Dietary Supplement 10 X 1 AAP
11 Methylcobalamin 500 mcg Vitamin B12 supplement 10 X 1 AAP NUROTHINTM
12 Zingiber officinale (Ginger) ... Sore throat, travel sickness, nausea and indigestion 10 X 1 AAP
13 Lactic acid bacillus 150 mss For the treatment of Irritable bowel syndrome and for treatment of diarrhea (Viral, traveler and antibiotics induced diarrhea) 10 X 1 AAP
14 Biotin 10000 mcg Treating and preventing biotin deficiency 10 X 1 AAP
15 Nicotin (Polacrilex) 4 For smoking cessation 10 X 1 AAP NICOTHINTM

Abbreviation: AAP = Alu-Alu Pouch

ZIM Labs Selected OTF Pipeline

Pharmaceutical products in developement stage

Product Code Thereputic Indication Formulation Developement Pilot Study Pivotal Study Regulatory Submission Market Launch
A00116Vitamin D Deficiency
A00747Migraine
--
A00121Migraine
--
B00026Erectile Dysfunction,
Bengin Prostatic Hyperlisia
B00079Erectile Dysfunction
B00027Diabetic Neuropathy
B00043Antidiabetic
--
B00026Antiasthmatic
B00029Antiallergic
A00197Anti Alzheimeric
-- --

OTF Film

WhatsAppWe're available to help you!