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Oral Thin Films (OTF) is the latest addition to ZIM Labs stable.

It is one of the few companies globally and one of the very few companies in India to have mastered OTF technology.

ZIM Labs Oral Thin Film (OTF) Technology is patented as Thinoral® with about 19 applied product/process patents for oral films globally.

It has received 24 DCGI product approvals & is awaiting 14 in India and 13 product approvals overseas.

Its rapidly dissolving, non-sticky films have a drug loading capacity as high as 100 mg of the active drug. The faster release profile alleviates solubility issues in poorly soluble drugs.

Unlike orally disintegrating tablets that are manufactured using lyophilization or low compression pressure, the Thinoral® strips are flexible and offer ease of storage and transportation.

Thinoral® technology could also be used for the delivery of drugs through sublingual & buccal absorption routes, showing improved bioavailability by avoiding first-pass metabolism.

Dry/Wet granulation and direct compression are the two methods for the preparation of tablets.

The prime advantage of direct compression over wet granulation is cost since the latter requires fewer unit operations. This means less equipment, lower power consumption, less space, time and labor leading to the reduced production cost of tablets.

Direct compression is more suitable for moisture and heat sensitive APIs since it eliminates wetting and drying steps and increases the stability of active ingredients by reducing detrimental effects.

Changes in dissolution profiles are less likely to occur in tablets made by direct compression on storage than in those made from granulations.

An added advantage to patients as they are not required to remember the timing for building up the required dosage in the human body.

Taste-masking techniques are applied to mask or overcome the bitter or unpleasant taste of active pharmaceutical ingredients/drugs to achieve patient acceptability and compliance.

Oral administration of bitter or unpleasant tasting drugs is often the biggest barrier for patient groups, such as pediatrics and geriatrics.

ZIM Labs has mastered this technology to make it not only cost-effective but also taste-mask bitter products including antibiotics, without affecting their shelf life while maintaining their dissolution and bioavailability requirements.

Pelletization, a niche technology, requires the adoption of a unique manufacturing process. Instead of the formulation being produced in powder form, the end product is in the form of fine micro granules called pellets.

Pellets give control on the time of the release of the dosage, in the required quantities in the body. The pellets are administered in capsules.

Sustained Release capsules are to be taken less than conventional dosage forms.

Dosage is released from the stomach in the body in the required proportion at the appropriate time of the day when it is required to be released, depending upon the typical disease.

An added advantage to patients as they are not required to remember the timing for building up the required dosage in the human body.

5

Doctorate

81

Post Graduate

22

Graduate

03

Diploma

R&D Patents

24 Inventions with 36 Patent Applications worldwide, out of which 2 Patents Granted

Modified Release Dosage Transformation Solubility Enhancement Taste Masking Total
291912262
THE BEST INNOVATION DEVELOPMENT OF A SOLID DOSAGE FORM

AWARD AND RECOGNITION

ZIM Labs fast-dissolving OTF was awarded the best innovation development of a solid dosage form for the year 2016 by India Pharmaceutical Association.

The Technology provides a unique opportunity to Pharmaceutical and Nutraceutial companies to create new brands or extent existing brand with a new dosage form.

Winner of "VIDARBHA UDYOG GAURAV" Award - 2019 Large Scale Industry

Winner of "VIDARBHA UDYOG GAURAV" Award - 2018 Best Exporter of The Region

Winner of "PHARMA EXPORT EXCELLENCE" Award - 2017

IAP ACG SciTech Award for "Best Innovation in Solid Dosage Form" for the year 2016 by India Pharmaceutical Association.

Winner of "Excellence in R&D" Award in 5th Annual India Pharma Awards. Nov-2017

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