How Novel Dosage Forms Make Medicines More Admissible

April 11, 2023

Drugs are rarely given as pure chemicals. Instead, they are given as prepared formulations, also in the most effective dosage forms. Non-medicinal chemicals, also called pharmaceutical ingredients or excipients, are added to the medicine to dosage variants. As the industry evolves and innovation takes shape, novel dosage forms will make the medicines more effective and appealing by adding pharmaceutical ingredients that dissolve, suspend, thicken, dilute, emulsify, stabilize, or preserve them.

The need for novel dosage forms

Novel dosage forms focus mostly on patient safety and enhancing the benefits of drugs. They can:

  • Offer exact doses safely and straightforwardly. Examples - Tablets, capsules, syrups
  • Hide the smell or taste of unpleasant drugs. For example, capsules, tablets with coatings, and flavored syrups
  • Offer drugs in a liquid form if the medicine doesn't dissolve or isn't stable. Example: Suspension
  • Enable controlled-release methods to make them effective for a longer time. Example: Tablets, capsules, and liquids with controlled release
  • Make drugs safe from stomach acid. Example: Tablets with an enteric coating
  • Give people the choice of how they want to use drugs that are put on the skin
  • Be injected into the body's tissues. Example – Implants
  • Provide a drug in a way where inhaling it becomes possible. Example: Inhalants
  • Be liquid and soluble in a chosen vehicle. Example-Rectal and vaginal suppositories
  • Keep a drug from being damaged by oxygen or moisture in the air. Example Covered pills and sealed ampoules

Examples and types of novel dosage forms

Solid Dosage Forms

Powders are often used as a solid dosage form. These are medicines that have been dried and broken up into small pieces. Powders are used both inside and outside the body. Effervescent powders release carbon dioxide when mixed with water, which makes the mixture taste better.

Capsules are small containers that are usually made of gelatin. One of the most common ways to take powder, oil, or liquids by mouth is in the form of a capsule. They break apart easily in the stomach so the contents can be absorbed. Capsules can be made with coatings that stop gastric juice from breaking down. When they reach the intestines, they dissolve in the alkaline juices and release the drug. Capsules can sometimes be given rectally or through the vaginal canal.

Tablets are solid dosage forms made by pressing or molding granulated or powdered drugs into round or other shapes. They can be made with or without diluents, and their size, shape, and weight can vary greatly. Along with the drug, tablets usually have a diluent, a disintegrator, a binder, and a lubricant. Diluents are used when the active ingredient is low, and the lubricant keeps the tablet from sticking to the machine. When it comes in contact with water, a disintegrator like starch makes the tablet swell, making it easy to break apart in the stomach. Tablets can be covered to make them taste better.

Pellets are multiparticulate dosage form which are formed by the agglomeration of fine powdered excipient and drugs together that leads to the formation of small free flowing spherical or semi spherical particles

Pills are made of powdered drugs mixed with substances that stick together. Tablets and capsules have since replaced these.

Lozenges or troches are various-shaped solid dosage forms, usually containing a medicinal agent and a flavoring substance, that are intended to be dissolved slowly in the oral cavity for localized or systemic effects.

Orally Dissolving Strips

Oral Thin Films are strips made from dissolvable materials that contain the Active Pharmaceutical Ingredient and quickly disintegrates when it gets in contact with saliva, starting the drug action immediately. 

Liquid Dosage Forms

One or more drugs are mixed with water to make Aqueous Solutions. There are two kinds: Solutions for oral use and solutions for injections (liquids or suspensions that are sterile and packed in proper containers). Most of the time, water and Sodium Chloride are used to make injections that come in sealed ampoules or vials made of glass.

Aqueous suspensions are made up of one or more drugs mixed into water with the help of harmless agents. These are mixtures of fine drugs that still need to be broken down. Suspensions are taken by mouth.

  • Emulsions are made when fats or oils are mixed with water and held in place with an emulsifying agent. The emulsifying agent coats the oil particles, so they don't stick together when the tension between the oil and water drops. So, you get a stable suspension. 
  • Gels are colloidal suspensions of hydrated inorganic materials in water.
  • Magmas are thick mixtures of materials that don't mix well with water. They are also known as "Milks" because they are white. Magmas and Gels are similar, but the particles in Magmas are more significant than those in Gels. So, Magmas tend to separate when left alone and need to be well shaken before use.
  • Mixtures are solutions or suspensions of one or more drugs meant to be taken by mouth.

How do they help in making medicines more administrable?

  • Better compliance and acceptance by patients
  • Better results
  • Fewer side effects
  • Fewer patient interventions
  • Allow patients to get medicines as outpatients
  • Less use of medical resources overall


Novel Dosage Forms are how drug molecules or APIs get to the parts of the body where they work so that they have the most positive and minor side effects. The Active Pharmaceutical Ingredients (API) and Excipients in the formulation make up the Dosage form.

About ZIM Laboratories

ZIM Labs is an innovative drug delivery solution provider focusing on improving patient convenience and adherence to drug intake. We offer a range of technology-based drug delivery solutions and non-infringing proprietary manufacturing processes to produce and supply innovative and differentiated generic pharmaceutical products to our customers globally. At ZIM Labs, we provide our customers with a comprehensive range of solid value-added dosage differentiated generic products in semi-finished and finished categories/formulations. These include granules, pellets (sustained, modified, extended-release), taste-masked powders, suspensions, tablets, capsules, and recently developed Oral Thin Films (OTF).


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